Focus sessions on 4 December 13.35h - 14.55h

Programmable peptide- and protein nanomaterials
Chair: Renko de Vries (WUR)

Developments in biotechnology, structural biology, peptide science, polymer science and molecular simulation are currently converging to allow for the rational design of sequences of peptides and proteins that self-assemble into predetermined nanostructures. This session showcases examples of such programmable peptide- and protein assembly, both from the Netherlands and from abroad.

  1. Jan Pille (TU/e): Pathway-dependent assembly of elastin-like peptide nanoparticles
  2. Aimee Boyle (LEI): Design and Characterisation of Peptides Containing Multinuclear Metal Centres
  3. Roman Jerala (National Institute of Chemistry, Slovenia): Coiled-coil protein origami

Novel reactivity leads to novel synthesis
Chair: Adri Minnaard (RUG)

Chemistry experiences a flurry of novel synthetic methods. Transformations once considered impossible are now carried out in one synthetic step. New synthons allow the construction of the carbon skeleton of a variety of natural products with unprecedented efficiency. This has immediate impact on fields like chemical biology and medicinal chemistry. 

  1. Johan Winne (Ghent University, Belgium): Traveling terpenoid chemical space with a heterocyclic cation
  2. Eelco Ruijter (VU): Ugi's legacy: from multicomponent reactions to natural product synthesis
  3. X. Yan (RUG): Direct addition of hard organometallics to conjugated non-protected carboxylic acids enabled by Lewis acids

Teaching and learning chemistry
Organised by KNCV
Chair: Fer Coenders (UT)

Three speakers present: 
- The KNCV Chemistry Teacher of 2017 will share why his chemistry teaching is highly valued by students.
- The Chemistry Media Centre project: bringing relevant information (video, text, website) into the classroom. 

  1. Joris Berding (Rotterdam Univ. of Appl. Sciences): what makes teaching highly valued?
  2. Renée Moezelaar and Jan-Willem Toering (KNCV): Chemistry Media Centre in the classroom
  3. Marijn Meijer (C3): Virtual Reality and Branched Video

Power/biomass to chemicals
Organised by Topsector Chemistry
Chair: André Heeres (Hanzehogeschool, Syncom)

The utilization of renewables and power/electricity for the synthesis of basic chemicals/polymers and efficient recycling systems are essential to achieve a transition towards a sustainable society. Within this session three speakers will present the synthesis/applications of green hydrogen and bio-aromatics and the chemical recycling of PET toward the corresponding monomers.

  1. Hans Lammers (AKZO Nobel): Green Hydrogen Technology
  2. Pieter Imhof (BioBTX): Bio-based production of cornerstone chemicals
  3. Vincent Voet (Stenden University): Recycling of Polyesters - Closing the Loops

Intact protein analysis
Organised by KNCV
Chair: Manfred Wuhrer (LUMC)

Proteins show considerable variation due to post-translational modifications, conformational changes and molecular interactions such as aggregate formation, thereby vastly influencing protein activity and function. This session will address the characterization of protein variants by native state mass spectrometric approaches, in conjunction with various separation techniques.

  1. Tomislav Caval (UU): Characterization of glycoengineered erythropoietins with native mass spectrometry
  2. Elena Dominguez Vega (VU): MS-based analytical techniques for the characterization of immunoglobulins
  3. Rob Haselberg (VU): Native separations coupled to mass spectrometry to enable intact protein structural and functional characterization

Chemistry of Cultural Heritage in a Historical Perspective
Organised by KNCV
Chair: Sven Dupré (UU)

Chemistry has helped us to understand the original appearance of objects, the impact of time, and to develop new, safe conservation methods. This session offers more insight into the nature of chemistry-based research in the field of cultural heritage, with emphasis on the development of this role through time.

  1. Mariana Pinto (UU): Chemists in the Field of Archaeology in the Nineteenth-Century
  2. Maartje Stols-Witlox (UvA): Recipes for Change: the Chemistry of Historical Restoration Recipes
  3. Maarten van Bommel (UvA): Discoloration of Cultural Heritage: Towards a Chemical Understanding of Fading of Artworks

Polyelectrolyte complexes
Chair: Jasper van der Gucht (WUR)

Polyelectrolyte complexes are important in a wide variety of application areas ranging from gene delivery platforms, membranes for desalination technology to ultra-tough solids, and are relevant in a biological context in the form of membrane-less organelles. In the focus session their role in both biology and materials sciences is highlighted. 

  1. Evan Spruijt (RU): Chemically active coacervates as protocell models
  2. Marco Dompe (WUR): Thermoresponsive complex coacervate-based underwater adhesives
  3. Esra te Brinke (UT): Asymmetric polyelectrolyte multilayer membranes for micropollutant removal

Designer materials inspired by nature
Chair: Nathalie Katsonis (UT)

Addressing current societal challenges in health and energy will require inventing radically new materials that respond to external triggers selectively and autonomously, and can adapt their function dynamically. In their quest for the next generation of designer materials, researchers draw inspiration from nature's adaptive molecular systems. 

  1. Thomas Speck (University of Freiburg): Bio-inspired materials systems: inspiration for technology and architecture in the 21st century
  2. Rienk Eelkema (TU Delft): Responsive chemical reaction networks in soft materials
  3. Marieke Gerth (TU Eindhoven): Dynamic assembly of helical supramolecular fibres

Integrative X-omics to understand the molecular building blocks of life
Chair: Thomas Hankemeier (LEI)

This session will address the understanding of the buildings blocks of lifes within the research line ‘Chemistry of Life’ including molecular biochemistry, structural biology and analytical chemistry. The research discussed within the session has impact on the life sciences, biotechnology, medicine, diagnostics, high tech systems and more.

  1. Alain van Gool (Radbound University Medical Centre): Innovation within the Netherlands X-omics Initiative
  2. Joep de Ligt (UMC Utrecht): Understanding cellular signalling in cancer using high-throughput multi-omics
  3. Maarten Altelaar (Utrecht University): Targeted MS for the high-throughput assessment of kinome-wide activation states
  4. Nelus Schoeman (Leiden University): Metabolomics in multi-omics - Applications challenges and future perspectives.